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Bioxan® Tocotrienols
What are Tocotrienols?
Tocotrienols are a variant form of natural Vitamin E, consisting of eight distinct molecules. These molecules are divided into two categories: tocopherols and tocotrienols. Each category contains four members, known as alpha, beta, delta, and gamma (Jiang et al., 2009).
Bioxan® Tocotrienols: The Next-Level Cosmetic Active for Inflammation and Antioxidant Protection
Tocotrienols are emerging as a highly beneficial active ingredient in the cosmetics industry, with exceptional advantages for skin health. While tocopherols are recognized for their antioxidant properties, tocotrienols offer superior benefits due to their unique anti-inflammatory capabilities. These properties are particularly valuable as consumers increasingly look for solutions for skin inflammation caused by environmental stressors and modern lifestyles.
Investigation of the Anti-Inflammatory Properties of Bioxan Rice Tocotrienol 50 and Bioxan Palm Tocotrienol 50
Chronic inflammation plays a crucial role in skin aging and the onset of inflammatory skin disorders. External stressors, such as ultraviolet (UV) radiation and environmental pollutants, can activate an inflammatory response in keratinocytes, leading to the release of pro-inflammatory cytokines, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and interleukin-8 (IL-8).
To assess the potential protective effects of two tocotrienol-rich fractions—Bioxan® Tocotrienol Rice 50 (Sample 1) and Bioxan Tocotrienol Palm 50 (Sample 2)—a study was conducted using an in vitro model with human keratinocytes.
Experimental Design
Human keratinocytes were cultured as a monolayer until full confluence was achieved. The cells were then exposed to an inflammatory agent (INVITOOLS™) in the presence or absence of the test samples to evaluate their effects on cytokine production. The levels of IL-1β, IL-6, and IL-8 in the cell culture supernatants were quantified after incubation.
Assessment of Cytokine Inhibition
To determine the extent of cytokine suppression, the collected samples were analyzed using a commercial enzyme-linked immunosorbent assay (ELISA) kit. Statistical comparisons were conducted using Student’s t-test to evaluate the significance of the observed effects.
Parameters Evaluated
- Inflammatory response: The production levels of IL-1β, IL-6, and IL-8, which are crucial markers of inflammation.
Results
- Sample 1 (Bioxan Tocotrienol Rice 50, 1%) exhibited a significant reduction in IL-8 production, highlighting its potential as an anti-inflammatory agent.
CAPACITY OF PROTECTION AGAINST IL-8 PRODUCTION (pg/ml)
- Sample 2 (Bioxan Tocotrienol Palm 50, 1%) demonstrated a broader inhibitory effect, significantly reducing the synthesis of IL-1β, IL-6, and IL-8, indicating a
CAPACITY OF PROTECTION AGAINST IL-1β PRODUCTION (pg/ml)
CAPACITY OF PROTECTION AGAINST IL-6 PRODUCTION (pg/ml)
CAPACITY OF PROTECTION AGAINST IL-8 PRODUCTION (pg/ml)
Conclusion
The findings suggest that both tocotrienol-based extracts possess anti-inflammatory properties. While Sample 1 effectively decreases IL-8 levels, Sample 2 provides a more extensive reduction in IL-1β, IL-6, and IL-8, positioning it as a strong candidate for mitigating chronic inflammation and delaying premature skin aging.
